{"id":4436,"date":"2022-07-04T12:24:47","date_gmt":"2022-07-04T10:24:47","guid":{"rendered":"https:\/\/dev.plasmaconcept.de\/nano-fx\/"},"modified":"2025-11-20T14:48:39","modified_gmt":"2025-11-20T13:48:39","slug":"nano-fx","status":"publish","type":"page","link":"https:\/\/dev.plasmaconcept.de\/en\/nano-fx\/","title":{"rendered":"nano fx"},"content":{"rendered":"<section class=\"l-section wpb_row us_custom_7259c537 slider_unterseite height_auto width_full\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_grid cols_1 laptops-cols_inherit tablets-cols_inherit mobiles-cols_1 valign_top type_default stacking_default\"><div class=\"wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"g-cols wpb_row arteficalslider via_grid cols_2 laptops-cols_inherit tablets-cols_inherit mobiles-cols_1 valign_top type_default reversed stacking_default\" style=\"--gap:0px;\"><div class=\"wpb_column vc_column_container us_custom_95304ca2 leftbox has_bg_color\"><div class=\"vc_column-inner\"><div class=\"wpb_text_column us_custom_cd781b90 hide_mobile has_text_color hide_on_laptops hide_on_tablets hide_on_mobiles\" id=\"nano_slider_text\"><div class=\"wpb_wrapper\"><h1 class=\"slidertypo\">The contemporary form of bone marrow stimulation<\/h1>\n<\/div><\/div><div class=\"wpb_text_column us_custom_cd781b90 hide_mobile has_text_color hide_on_default\"><div class=\"wpb_wrapper\"><h1 class=\"slidertypo\">The contemporary form of bone marrow<br \/>\nstimulation<\/h1>\n<\/div><\/div><div class=\"wpb_text_column us_custom_6df4bc3a has_text_color\"><div class=\"wpb_wrapper\"><p>NanoFx<sup>\u00ae<\/sup> is a system for bone marrow stimulation that provides a standardized procedure for nanofracturing. By deeply perforating the subchondral plate and the sub-articular cancellous bone, direct access channels to the marrow cavity are created, allowing mesenchymal stem cells (MSC) to infiltrate the cartilage defect.<\/p>\n<\/div><\/div><\/div><\/div><div class=\"wpb_column vc_column_container us_custom_e032691c rightbox has_bg_color\"><div class=\"vc_column-inner\"><div class=\"w-html\"><div class=\"desk-spacer\" style=\"height:500px;\"><\/div>\n<div class=\"mobile-spacer\" style=\"height:0px;\"><\/div><\/div><div class=\"w-html\"><div style=\"clear:both;\"><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row schmallercontentprodukte24 height_medium\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_grid cols_1 laptops-cols_inherit tablets-cols_inherit mobiles-cols_1 valign_top type_default stacking_default\"><div class=\"wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><h1>Convincing one-step cartilage regeneration with the combination of NanoFx<sup>\u00ae<\/sup> and Hyalofast<sup>\u00ae<\/sup><\/h1>\n<\/div><\/div><div class=\"wpb_text_column us_custom_8e09cc6b\"><div class=\"wpb_wrapper\"><p>NanoFx\u00ae and Hyalofast\u00ae offer a modern therapeutic concept for the treatment of chondral and osteochondral defects. Nanofracturing is a standardized procedure for recruiting mesenchymal stem cells (MSC) from the marrow cavity. Matrix-augmented cartilage regeneration with Hyalofast\u00ae promotes MSC differentiation through the biological activity of hyaluronic acid, supporting chondrogenesis. Thus, NanoFx\u00ae and Hyalofast\u00ae complement each other to form an optimal treatment concept for cartilage defects.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row us_custom_a4fbd29b breiterebloecke height_auto width_full\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_grid cols_3 laptops-cols_inherit tablets-cols_inherit mobiles-cols_1 valign_top type_default stacking_default\" style=\"--gap:20px;\"><div class=\"wpb_column vc_column_container highlightboxprodukt ngray1\"><div class=\"vc_column-inner\"><div class=\"wpb_text_column produktehighlightbox\"><div class=\"wpb_wrapper\"><h4>Standardized procedure<\/h4>\n<ul>\n<li>Controlled depth of 9 mm and narrow 1 mm diameter<\/li>\n<li>Reusable instrument with sharp single-use needles<\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div><div class=\"wpb_column vc_column_container highlightboxprodukt ngray2\"><div class=\"vc_column-inner\"><div class=\"wpb_text_column produktehighlightbox\"><div class=\"wpb_wrapper\"><h4>Superior bone marrow stimulation<\/h4>\n<ul>\n<li>Increased stem cell yield due to deeper perforation<\/li>\n<li>Improved defect filling with a high proportion of type 2 collagen<\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div><div class=\"wpb_column vc_column_container highlightboxprodukt ngray3\"><div class=\"vc_column-inner\"><div class=\"wpb_text_column produktehighlightbox\"><div class=\"wpb_wrapper\"><p>ChatGPT:<\/p>\n<h4>Easy and safe application<\/h4>\n<ul>\n<li>Smooth and rapid perforation<\/li>\n<li>Facilitates the restoration of subchondral bone<\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row schmallercontentprodukte24 height_medium\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_grid cols_1 laptops-cols_inherit tablets-cols_inherit mobiles-cols_1 valign_top type_default stacking_default\"><div class=\"wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"w-tabs layout_hor style_trendy switch_click\" style=\"--sections-title-size:1em\"><div class=\"w-tabs-list items_3 align_none\"><div class=\"w-tabs-list-h\"><button class=\"w-tabs-item active\" aria-controls=\"content-h879\" aria-expanded=\"false\"><span class=\"w-tabs-item-title\">Nanofracture<\/span><\/button><button class=\"w-tabs-item\" aria-controls=\"content-u238\" aria-expanded=\"false\"><span class=\"w-tabs-item-title\">One-Step Cartilage Regeneration<\/span><\/button><button class=\"w-tabs-item\" aria-controls=\"content-bbb4\" aria-expanded=\"false\"><span class=\"w-tabs-item-title\">Short and compact<\/span><\/button><\/div><\/div><div class=\"w-tabs-sections titles-align_none icon_chevron cpos_right\"><div class=\"w-tabs-section active\" id=\"h879\"><button class=\"w-tabs-section-header active\" aria-controls=\"content-h879\" aria-expanded=\"true\"><div class=\"w-tabs-section-title\">Nanofracture<\/div><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-h879\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"wpb_text_column us_custom_8e09cc6b\"><div class=\"wpb_wrapper\"><h2>Nanofracturing with NanoFx<sup>\u00ae<\/sup><\/h2>\n<\/div><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Microfracturing is increasingly being criticized as a treatment option for focal cartilage defects and, according to professional societies and cartilage experts, should only be used in exceptional cases. Nanofracturing offers an effective alternative for the treatment of chondral and osteochondral defects. NanoFx<sup>\u00ae<\/sup> is a system for bone marrow stimulation that provides a standardized procedure for nanofracturing. By deeply perforating the subchondral plate and the sub-articular cancellous bone, direct access channels to the marrow cavity are created, allowing mesenchymal stem cells (MSC) to infiltrate the cartilage defect. This bleeding, accompanied by the recruitment of MSC, is essential for cartilage regeneration. Through the 9 mm deep perforation achieved with NanoFx<sup>\u00ae<\/sup>, high yields of MSC can be obtained, promoting high-quality cartilage regeneration with a hyaline-like character. In addition, the 1 mm thin diameter helps preserve the subchondral plate and cancellous bone, aiming to support rapid healing and restoration of the subchondral bone.<\/p>\n<\/div><\/div><div class=\"w-image us_custom_b4c0c321 align_none\"><div class=\"w-image-h\"><img decoding=\"async\" width=\"2416\" height=\"920\" src=\"https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2022\/07\/Vergleich_Mfx_Nfx_Schematisch_DE.png\" class=\"attachment-full size-full\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2022\/07\/Vergleich_Mfx_Nfx_Schematisch_DE.png 2416w, https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2022\/07\/Vergleich_Mfx_Nfx_Schematisch_DE-300x114.png 300w, https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2022\/07\/Vergleich_Mfx_Nfx_Schematisch_DE-1024x390.png 1024w\" sizes=\"auto, (max-width: 2416px) 100vw, 2416px\" \/><\/div><\/div><div class=\"wpb_text_column bildunterschrift\"><div class=\"wpb_wrapper\"><p>Schematic comparison of microfracturing vs. nanofracturing with NanoFx\u00ae<\/p>\n<\/div><\/div><div class=\"w-separator size_small with_line width_default thick_1 style_solid color_border align_center\"><div class=\"w-separator-h\"><\/div><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><h3>The contemporary form of bone marrow stimulation<\/h3>\n<\/div><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p style=\"color: #005da9;\">Comparison of nanofracturing with microfracturing and K-wire drilling<\/p>\n<p>An in-vivo comparative study in adult sheep provides insight into the subchondral differences between three methods of bone marrow stimulation and their effects on trabecular bone structure.<\/p>\n<\/div><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>(\u25b3) open trabecular channels; (\u25b2) closed trabecular channels; microCT comparison: axial (top), sagittal (bottom)<\/p>\n<\/div><\/div><div class=\"g-cols wpb_row us_custom_bcf7e3f8 via_grid cols_3 laptops-cols_inherit tablets-cols_inherit mobiles-cols_1 valign_top type_default stacking_default\" style=\"--gap:3rem;\"><div class=\"wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"w-image us_custom_856d843b align_center\"><div class=\"w-image-h\"><img decoding=\"async\" width=\"279\" height=\"356\" src=\"https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2022\/07\/image01_1.png\" class=\"attachment-full size-full\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2022\/07\/image01_1.png 279w, https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2022\/07\/image01_1-235x300.png 235w\" sizes=\"auto, (max-width: 279px) 100vw, 279px\" \/><\/div><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Microfracturing: Trabecular wall thickness and density increase due to bone compression; limited number of open trabecular channels; canal edges with non-anatomical uniformity (left). Peripheral canal edges: crushed and dense bone deposits (right).<\/p>\n<\/div><\/div><\/div><\/div><div class=\"wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"w-image us_custom_856d843b align_center\"><div class=\"w-image-h\"><img decoding=\"async\" width=\"274\" height=\"356\" src=\"https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2022\/07\/image01_2.png\" class=\"attachment-full size-full\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2022\/07\/image01_2.png 274w, https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2022\/07\/image01_2-231x300.png 231w\" sizes=\"auto, (max-width: 274px) 100vw, 274px\" \/><\/div><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Nanofracturing: Trabecular wall thickness and density appear normal; high number of open trabecular channels; anatomical irregularities of the canal edges intact (left). Peripheral canal edges: porous, fragmented bone deposits (right).<\/p>\n<\/div><\/div><\/div><\/div><div class=\"wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"w-image us_custom_856d843b align_center\"><div class=\"w-image-h\"><img decoding=\"async\" width=\"276\" height=\"356\" src=\"https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2022\/07\/image01_3.png\" class=\"attachment-full size-full\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2022\/07\/image01_3.png 276w, https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2022\/07\/image01_3-233x300.png 233w\" sizes=\"auto, (max-width: 276px) 100vw, 276px\" \/><\/div><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>1 mm K-wire: Trabecular wall thickness and density are nearly normal; limited number of open trabecular channels; canal edges with non-anatomical uniformity (left). Peripheral canal edges: crushed and dense bone deposits (right)<\/p>\n<\/div><\/div><\/div><\/div><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>It was shown that <strong>microfracturing<\/strong> with a conventional awl (diameter approx. 2.5 mm, images left) resulted in superficial perforations with compression of the cancellous bone. In this procedure, the number of open trabecular channel accesses is limited, and both channel depth and diameter are highly variable and depend on the user\u2019s technique and the instruments used.<\/p>\n<p><strong>K-wire drilling<\/strong> (diameter 1 mm, images right) produced straight canal walls, whereas open trabecular channels were limited. Motor-assisted drilling can generate rotational heat and press the drilled tissue against the canal edges. This leads to the closure of trabecular channel openings. The diameter of the wire is standardized, but the depth of the procedure is highly variable, as it must be visually controlled.<\/p>\n<p><strong>Nanofracturing<\/strong> with NanoFx<sup>\u00ae<\/sup> (middle images) achieved deep perforations of the cancellous bone with a high number of open trabecular channels without generating rotational heat. In contrast to microfracturing, nanofracturing is standardized with a controlled depth of 9 mm and a diameter of 1 mm, increasing the comparability and reproducibility of this procedure.<\/p>\n<\/div><\/div><div class=\"g-cols wpb_row via_grid cols_1 laptops-cols_inherit tablets-cols_inherit mobiles-cols_1 valign_top type_default stacking_default\" style=\"--gap:3rem;\"><div class=\"wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"w-image us_custom_900b47d4 align_center\"><div class=\"w-image-h\"><img decoding=\"async\" width=\"300\" height=\"250\" src=\"https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2022\/07\/image02.jpg\" class=\"attachment-full size-full\" alt=\"\" loading=\"lazy\" \/><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"w-tabs-section\" id=\"u238\"><button class=\"w-tabs-section-header\" aria-controls=\"content-u238\" aria-expanded=\"false\"><div class=\"w-tabs-section-title\">One-Step Cartilage Regeneration<\/div><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-u238\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><h3>Fast and easy application<\/h3>\n<\/div><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>The NanoFx<sup>\u00ae<\/sup> guide can be inserted into the defect arthroscopically or minimally invasively and does not require any specific incisions. With the sterile single-use needle, a sharp instrument is always available to perforate the subchondral plate. NanoFx<sup>\u00ae<\/sup> is easy to assemble and therefore quickly ready for use. Compared to microfracturing, the force of the hammer strike is optimally transferred to the 1 mm thin tip of the needle, meaning that even light taps are sufficient. Thanks to the integrated depth stop, the needle is always inserted in a controlled manner to a depth of 9 mm into the cancellous bone. Application of NanoFx<sup>\u00ae<\/sup>:<\/p>\n<\/div><\/div><div class=\"g-cols wpb_row via_grid cols_1 laptops-cols_inherit tablets-cols_inherit mobiles-cols_1 valign_top type_default stacking_default\" style=\"--gap:3rem;\"><div class=\"wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"w-image us_custom_a3e30414 align_none\"><div class=\"w-image-h\"><img decoding=\"async\" width=\"1024\" height=\"521\" src=\"https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2022\/07\/anwendungen-1024x521-1.png\" class=\"attachment-full size-full\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2022\/07\/anwendungen-1024x521-1.png 1024w, https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2022\/07\/anwendungen-1024x521-1-300x153.png 300w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/div><\/div><\/div><\/div><\/div><div class=\"wpb_text_column bildunterschrift\"><div class=\"wpb_wrapper\"><p>The NanoFx<sup>\u00ae<\/sup> guide is reusable and must be cleaned and sterilized after use.<\/p>\n<\/div><\/div><\/div><\/div><\/div><div class=\"w-tabs-section\" id=\"bbb4\"><button class=\"w-tabs-section-header\" aria-controls=\"content-bbb4\" aria-expanded=\"false\"><div class=\"w-tabs-section-title\">Short and compact<\/div><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-bbb4\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Product: NanoFx\u00ae \u2013 instrument for bone marrow stimulation Items: NanoFx\u00ae guide, PleuriStik nitinol needle, thumb tab Approval: Medical device with CE marking Sterilization: Gamma sterilized Storage: Store dry<\/p>\n<\/div><\/div><div class=\"g-cols wpb_row via_grid cols_2 laptops-cols_inherit tablets-cols_inherit mobiles-cols_1 valign_top type_default stacking_default\" style=\"--gap:3rem;\"><div class=\"wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"w-image align_none\"><div class=\"w-image-h\"><img decoding=\"async\" width=\"1024\" height=\"350\" src=\"https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2022\/07\/IMG_1695-1024x350-1.jpg\" class=\"attachment-full size-full\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2022\/07\/IMG_1695-1024x350-1.jpg 1024w, https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2022\/07\/IMG_1695-1024x350-1-300x103.jpg 300w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/div><\/div><div class=\"wpb_text_column bildunterschrift\"><div class=\"wpb_wrapper\"><p>NanoFx<sup>\u00ae<\/sup> guide (e.g., knee, shoulder)<\/p>\n<\/div><\/div><\/div><\/div><div class=\"wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"w-image align_none\"><div class=\"w-image-h\"><img decoding=\"async\" width=\"1024\" height=\"350\" src=\"https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2022\/07\/IMG_1653-1024x350-1.png\" class=\"attachment-full size-full\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2022\/07\/IMG_1653-1024x350-1.png 1024w, https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2022\/07\/IMG_1653-1024x350-1-300x103.png 300w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/div><\/div><div class=\"wpb_text_column bildunterschrift\"><div class=\"wpb_wrapper\"><p>NanoFx<sup>\u00ae<\/sup> guide A-Curve (e.g., upper ankle joint)<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"w-separator size_medium with_line width_default thick_1 style_solid color_border align_center\"><div class=\"w-separator-h\"><\/div><\/div><div class=\"wpb_text_column us_custom_15f9d3f2\"><div class=\"wpb_wrapper\"><h2>More knowledge, more movement<\/h2>\n<\/div><\/div><div class=\"w-tabs style_default switch_click accordion\" style=\"--sections-title-size:inherit\"><div class=\"w-tabs-sections titles-align_none icon_chevron cpos_right\"><div class=\"w-tabs-section\" id=\"w219\"><button class=\"w-tabs-section-header\" aria-controls=\"content-w219\" aria-expanded=\"false\"><div class=\"w-tabs-section-title\">Development of nanofracture<\/div><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-w219\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Bone marrow stimulation for the recruitment of progenitor cells into the cartilage defect is a well-established therapeutic option in cartilage regeneration. Since the late 1980s, microfracturing has developed into the primary treatment choice due to its low cost, relatively low morbidity, and encouraging results as a first-line procedure for cartilage defects, especially in young and active patients (1\u20133).<\/p>\n<p>Renewed interest in the effects on the subchondral bone shed new light on the limitations of microfracturing: shallow channels, wall compression, and an increase in trabecular wall thickness and density were observed via CT and histology (4\u20136). Chen et al. reported that deeper subchondral bone marrow stimulation resulted in better cartilage defect filling, more type II collagen, and less type I collagen compared to shallow bone marrow access (5). A study by Eldracher et al. (7) showed that 1 mm drill holes resulted in improved histology, cancellous bone restoration, and immunoreactivity toward type II collagen compared to 1.8 mm drill holes.<\/p>\n<p>The non-standardized depth, diameter, and perforation density of microfracturing led to the development of a new method for perforating the subchondral plate (nanofracturing), which provides a standardized depth of 9 mm and a diameter of 1 mm.<\/p>\n<\/div><\/div><div class=\"g-cols wpb_row us_custom_6a2e7e2d via_grid cols_2 laptops-cols_inherit tablets-cols_inherit mobiles-cols_1 valign_top type_default stacking_default\" style=\"--gap:3rem;\"><div class=\"wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"w-image align_none\"><div class=\"w-image-h\"><img decoding=\"async\" width=\"624\" height=\"404\" src=\"https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2022\/07\/image03.jpg\" class=\"attachment-full size-full\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2022\/07\/image03.jpg 624w, https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2022\/07\/image03-300x194.jpg 300w\" sizes=\"auto, (max-width: 624px) 100vw, 624px\" \/><\/div><\/div><\/div><\/div><div class=\"wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"w-image align_none\"><div class=\"w-image-h\"><img decoding=\"async\" width=\"624\" height=\"404\" src=\"https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2022\/07\/image04.jpg\" class=\"attachment-full size-full\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2022\/07\/image04.jpg 624w, https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2022\/07\/image04-300x194.jpg 300w\" sizes=\"auto, (max-width: 624px) 100vw, 624px\" \/><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"w-tabs-section\" id=\"j62b\"><button class=\"w-tabs-section-header\" aria-controls=\"content-j62b\" aria-expanded=\"false\"><div class=\"w-tabs-section-title\">Literature<\/div><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-j62b\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"wpb_text_column us_custom_38c9f838\"><div class=\"wpb_wrapper\"><h2>Literature<\/h2>\n<ol>\n<li style=\"margin-bottom: 20px;\">Kreuz PC, Steinwachs MR, Erggelet C, Krause SJ, Konrad G, Uhl M, S\u00fcdkamp N. Results after microfracture of full-thickness chondral defects in different compartments in the knee. Osteoarthritis Cartilage. 2006 Nov;14(11):1119\u201325.<\/li>\n<li style=\"margin-bottom: 20px;\">Mithoefer K, Williams RJ 3rd, Warren RF, Potter HG, Spock CR, Jones EC, Wickiewicz TL, Marx RG. The microfracture technique for the treatment of articular cartilage lesions in the knee. A prospective cohort study. J Bone Joint Surg Am. 2005 Sep;87(9):1911\u201320.<\/li>\n<li style=\"margin-bottom: 20px;\">Steadman JR, Briggs KK, Rodrigo JJ, Kocher MS, Gill TJ, Rodkey WG. Outcomes of microfracture for traumatic chondral defects of the knee: average 11-year follow-up. Arthroscopy. 2003 May\u2013Jun;19(5):477\u201384.<\/li>\n<li style=\"margin-bottom: 20px;\">Chen H, Sun J, Hoemann CD, Lascau-Coman V, Ouyang W, McKee MD, Shive MS, Buschmann MD. Drilling and microfracture lead to different bone structure and necrosis during bone-marrow stimulation for cartilage repair. J Orthop Res. 2009 Nov;27(11):1432\u20138.<\/li>\n<li style=\"margin-bottom: 20px;\">Chen H, Hoemann CD, Sun J, Chevrier A, McKee MD, Shive MS, Hurtig M, Buschmann MD. Depth of subchondral perforation influences the outcome of bone marrow stimulation cartilage repair. J Orthop Res. 2011 Aug;29(8):1178\u201384.<\/li>\n<li style=\"margin-bottom: 20px;\">Fortier LA, Cole BJ, McIlwraith CW. Science and animal models of marrow stimulation for cartilage repair. J Knee Surg. 2012 Mar;25(1):3\u20138.<\/li>\n<li style=\"margin-bottom: 20px;\">Eldracher M. et al. Small Subchondral Drill Holes Improve Marrow Stimulation of Articular Cartilage Defects. Am J Sports Med. 2014 Nov;42(11):2741\u201350.<\/li>\n<\/ol>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section>\n","protected":false},"excerpt":{"rendered":"The contemporary form of bone marrow stimulation The contemporary form of bone marrow stimulation NanoFx\u00ae is a system for bone marrow stimulation that provides a standardized procedure for nanofracturing. 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