{"id":4424,"date":"2024-07-16T17:05:12","date_gmt":"2024-07-16T15:05:12","guid":{"rendered":"https:\/\/dev.plasmaconcept.de\/lipo-stem-duo\/"},"modified":"2025-11-19T12:48:37","modified_gmt":"2025-11-19T11:48:37","slug":"lipo-stem-duo","status":"publish","type":"page","link":"https:\/\/dev.plasmaconcept.de\/en\/lipo-stem-duo\/","title":{"rendered":"Lipo Stem Duo"},"content":{"rendered":"<section class=\"l-section wpb_row us_custom_da401357 slider_unterseite height_auto width_full\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_grid cols_1 laptops-cols_inherit tablets-cols_inherit mobiles-cols_1 valign_top type_default stacking_default\"><div class=\"wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"g-cols wpb_row arteficalslider via_grid cols_2 laptops-cols_inherit tablets-cols_inherit mobiles-cols_1 valign_top type_default reversed stacking_default\" style=\"--gap:0px;\"><div class=\"wpb_column vc_column_container us_custom_95304ca2 leftbox has_bg_color\"><div class=\"vc_column-inner\"><div class=\"wpb_text_column us_custom_cd781b90 hide_mobile has_text_color\"><div class=\"wpb_wrapper\"><h1 class=\"slidertypo\">Autologous adipose tissue in osteoarthritis<\/h1>\n<\/div><\/div><div class=\"wpb_text_column us_custom_6df4bc3a has_text_color\"><div class=\"wpb_wrapper\"><p>In recent years, many non-surgical options for treating osteoarthritis have become established in Europe. Particularly popular are injections with orthobiologics such as platelet-rich plasma (PRP), hyaluronic acid (HA), and bone marrow aspirate\/concentrate (BMA\/BMAC). In addition, adipose tissue has proven to be a novel and attractive source of stem cells and thus for regenerative medicine. 1,2<\/p>\n<\/div><\/div><\/div><\/div><div class=\"wpb_column vc_column_container us_custom_e032691c rightbox has_bg_color\"><div class=\"vc_column-inner\">[vc_raw_html]JTNDZGl2JTIwY2xhc3MlM0QlMjJkZXNrLXNwYWNlciUyMiUyMHN0eWxlJTNEJTIyaGVpZ2h0JTNBNTAwcHglM0IlMjIlM0UlM0MlMkZkaXYlM0UlMEElM0NkaXYlMjBjbGFzcyUzRCUyMm1vYmlsZS1zcGFjZXIlMjIlMjBzdHlsZSUzRCUyMmhlaWdodCUzQTBweCUzQiUyMiUzRSUzQyUyRmRpdiUzRQ==[\/vc_raw_html][vc_raw_html]JTNDZGl2JTIwc3R5bGUlM0QlMjJjbGVhciUzQWJvdGglM0IlMjIlM0UlM0MlMkZkaXYlM0U=[\/vc_raw_html]<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row schmallercontentprodukte24 height_medium\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_grid cols_1 laptops-cols_inherit tablets-cols_inherit mobiles-cols_1 valign_top type_default stacking_default\"><div class=\"wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_text_column produkt_intro_text\"><div class=\"wpb_wrapper\"><h2>Microfragmentation and purification of mesenchymal stem cells from adipose tissue<\/h2>\n<p>Stem cell therapy describes a procedure in which stem cells from the patient and other potentially regenerative cells are first obtained from a tissue sample: either from bone marrow or from the stromal vascular fraction (SVF) of adipose tissue. These regenerative cells can be used to treat various defects. The cells are either injected directly into or at the site of the defect, or they can be used in combination with a carrier material. 4<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row us_custom_a4fbd29b breiterebloecke height_auto width_full\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_grid cols_3 laptops-cols_inherit tablets-cols_inherit mobiles-cols_1 valign_top type_default stacking_default\" style=\"--gap:20px;\"><div class=\"wpb_column vc_column_container highlightboxprodukt lsgreen1\"><div class=\"vc_column-inner\"><div class=\"wpb_text_column produktehighlightbox\"><div class=\"wpb_wrapper\"><h4>Time-saving<\/h4>\n<ul>\n<li>Microfragments up to 400 ml of adipose tissue in 10 minutes<\/li>\n<li>No centrifuge required: saves time, staff, and equipment<\/li>\n<li>All-in-one system: processes, cleans, and microfragments adipose tissue simultaneously<\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div><div class=\"wpb_column vc_column_container highlightboxprodukt lsgreen2\"><div class=\"vc_column-inner\"><div class=\"wpb_text_column produktehighlightbox\"><div class=\"wpb_wrapper\"><h4>Minimal manipulation<\/h4>\n<ul>\n<li>No enzymes, no centrifugation \u2013 instead, minimal stress for the cells and the surrounding extracellular matrix 3<\/li>\n<li>Preservation of the biological characteristics of the stromal vascular fraction including the surrounding matrix &rarr; maximization of the regenerative potential 3<\/li>\n<li>Harvesting and processing in a sterile environment within a closed system<\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div><div class=\"wpb_column vc_column_container highlightboxprodukt lsgreen3\"><div class=\"vc_column-inner\"><div class=\"wpb_text_column produktehighlightbox\"><div class=\"wpb_wrapper\"><h4>Easy handling<\/h4>\n<ul>\n<li>Simple and reproducible procedure in a single surgical session<\/li>\n<li>Minimization of training, preparation, and cleaning time<\/li>\n<li>Only one operator required<\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row schmallercontentprodukte24 height_medium\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_grid cols_1 laptops-cols_inherit tablets-cols_inherit mobiles-cols_1 valign_top type_default stacking_default\"><div class=\"wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"w-tabs layout_hor style_trendy switch_click\" style=\"--sections-title-size:1em\"><div class=\"w-tabs-list items_3 align_none\"><div class=\"w-tabs-list-h\"><button class=\"w-tabs-item active\" aria-controls=\"content-y85c\" aria-expanded=\"false\"><span class=\"w-tabs-item-title\">Lipo-Stem Duo\u2122 Kit<\/span><\/button><button class=\"w-tabs-item\" aria-controls=\"content-vdb5\" aria-expanded=\"false\"><span class=\"w-tabs-item-title\">Harvesting the SVF<\/span><\/button><button class=\"w-tabs-item\" aria-controls=\"content-d663\" aria-expanded=\"false\"><span class=\"w-tabs-item-title\">Short and concise<\/span><\/button><\/div><\/div><div class=\"w-tabs-sections titles-align_none icon_chevron cpos_right\"><div class=\"w-tabs-section active\" id=\"y85c\"><button class=\"w-tabs-section-header active\" aria-controls=\"content-y85c\" aria-expanded=\"true\"><div class=\"w-tabs-section-title\">Lipo-Stem Duo\u2122 Kit<\/div><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-y85c\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"w-image us_custom_8d5aa4e2 align_none\"><a ref=\"magnificPopup\" href=\"https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2024\/07\/lipo_stem_duo_content_image1.jpg\" aria-label=\"lipo_stem_duo_content_image1\" class=\"w-image-h\"><img decoding=\"async\" width=\"2421\" height=\"1054\" src=\"https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2024\/07\/lipo_stem_duo_content_image1.jpg\" class=\"attachment-full size-full\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2024\/07\/lipo_stem_duo_content_image1.jpg 2421w, https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2024\/07\/lipo_stem_duo_content_image1-300x131.jpg 300w, https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2024\/07\/lipo_stem_duo_content_image1-1024x446.jpg 1024w\" sizes=\"auto, (max-width: 2421px) 100vw, 2421px\" \/><\/a><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>a) Lipo-Stem Duo\u2122 processing device with filter bag (400 ml) for the lipoaspirate fluid, as well as a pre-attached waste collection bag (2 liters) and an open slide clamp<br \/>\nb) Processing spatula to support gentle microfragmentation and purification of adipose tissue<br \/>\nc) Two 60 ml disposable syringes for injection of the Klein solution<br \/>\nd) Two 60 ml Vaclok syringes for lipoaspiration<br \/>\ne) One infusion set with outlet plug, clamp, and spike for piercing the saline bag<br \/>\nf) Two 10 ml infusion syringes for collecting the final product<br \/>\ng) Two 3 ml infusion syringes for injecting the final product<br \/>\nh) One 20 G \u00d7 90 mm injection cannula<br \/>\ni) One 16 G infiltration cannula for infiltration of the Klein solution<br \/>\nj) One 13 G infiltration cannula for lipoaspiration<br \/>\nk) Two combination caps (LLF\/LLM) for sealing syringes (g and h)<br \/>\nl) Two adapters (Luer connection female; LLF\/LLF) for connecting two syringes<\/p>\n<\/div><\/div><\/div><\/div><\/div><div class=\"w-tabs-section\" id=\"vdb5\"><button class=\"w-tabs-section-header\" aria-controls=\"content-vdb5\" aria-expanded=\"false\"><div class=\"w-tabs-section-title\">Harvesting the SVF<\/div><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-vdb5\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"wpb_text_column us_custom_15f9d3f2\"><div class=\"wpb_wrapper\"><h3>Lipo-Stem Duo\u2122 for harvesting the SVF<\/h3>\n<\/div><\/div><div class=\"g-cols wpb_row via_grid cols_2 laptops-cols_inherit tablets-cols_inherit mobiles-cols_1 valign_top type_default stacking_default\" style=\"--gap:3rem;\"><div class=\"wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Lipo-Stem Duo\u2122 is a CE-marked, sterile single-use medical device. Without centrifugation, without enzymes, and with only minimal manipulation, the special filter system in a closed circuit ensures consistent microfragmentation and purification of adipose tissue. In doing so, the biological properties are preserved and the regenerative potential of the cells is maximized.<\/p>\n<\/div><\/div><\/div><\/div><div class=\"wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>The entire processing of the aspirated tissue takes place within the closed filter system and, thanks to continuous flushing with saline, is gentle on the cells. In this way, cellular stress is reduced and any traumatic impact that could damage the extracellular matrix and its trophic and anti-inflammatory function is avoided.<\/p>\n<\/div><\/div><\/div><\/div><\/div><div class=\"g-cols wpb_row us_custom_c3204e27 via_grid cols_2-1 laptops-cols_inherit tablets-cols_inherit mobiles-cols_1 valign_top type_default stacking_default\" style=\"--gap:3rem;\"><div class=\"wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p><strong>The green Lipo-Stem Duo\u2122 cassette is equipped with two filters:<\/strong><\/p>\n<ul>\n<li>The first filter, with its coarser structure, microfragments the aspirated adipose tissue while fibrotic tissue is filtered out.<\/li>\n<li>The second filter, with a very fine mesh, retains the microfragmented adipose tissue containing the SVF, while it is continuously flushed with saline. This removes all oil and blood residues that could otherwise cause inflammation of the treated tissue.<\/li>\n<\/ul>\n<\/div><\/div><div class=\"wpb_text_column us_custom_972c33a7\"><div class=\"wpb_wrapper\"><p>The final product obtained is a finely liquefied, autologous adipose tissue that preserves the biological characteristics of the original tissue and can be easily injected even through very fine needles.<\/p>\n<\/div><\/div><\/div><\/div><div class=\"wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"w-image us_custom_dd0d88e3 align_left\"><div class=\"w-image-h\"><img decoding=\"async\" width=\"777\" height=\"2159\" src=\"https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2024\/07\/lipo_stem_duo_content_image2.jpg\" class=\"attachment-full size-full\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2024\/07\/lipo_stem_duo_content_image2.jpg 777w, https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2024\/07\/lipo_stem_duo_content_image2-108x300.jpg 108w, https:\/\/dev.plasmaconcept.de\/wp-content\/uploads\/2024\/07\/lipo_stem_duo_content_image2-369x1024.jpg 369w\" sizes=\"auto, (max-width: 777px) 100vw, 777px\" \/><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"w-tabs-section\" id=\"d663\"><button class=\"w-tabs-section-header\" aria-controls=\"content-d663\" aria-expanded=\"false\"><div class=\"w-tabs-section-title\">Short and concise<\/div><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-d663\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"g-cols wpb_row via_grid cols_2 laptops-cols_inherit tablets-cols_inherit mobiles-cols_1 valign_top type_default stacking_default\" style=\"--gap:3rem;\"><div class=\"wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p><strong>Product:<\/strong> System for aspiration, processing, and reimplantation of autologous adipose tissue<br \/>\n<strong>Approval:<\/strong> Medical device with CE marking<br \/>\n<strong>Sterilization:<\/strong> Double sterile packaging<br \/>\n<strong>Sterilization method:<\/strong> Ethylene oxide (EO), sterilized according to ISO 11135<br \/>\n<strong>Outer packaging dimensions:<\/strong> 43.5 cm (L) \u00d7 29.2 cm (W) \u00d7 12 cm (H)<\/p>\n<\/div><\/div><\/div><\/div><div class=\"wpb_column vc_column_container\"><div class=\"vc_column-inner\"><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"w-separator size_medium with_line width_default thick_1 style_solid color_border align_center\"><div class=\"w-separator-h\"><\/div><\/div><div class=\"wpb_text_column us_custom_15f9d3f2\"><div class=\"wpb_wrapper\"><h2>More Knowledge, More Movement<\/h2>\n<\/div><\/div><div class=\"w-tabs style_default switch_click accordion\" style=\"--sections-title-size:inherit\"><div class=\"w-tabs-sections titles-align_none icon_chevron cpos_right\"><div class=\"w-tabs-section\" id=\"k93f\"><button class=\"w-tabs-section-header\" aria-controls=\"content-k93f\" aria-expanded=\"false\"><div class=\"w-tabs-section-title\">Stromal vascular fraction<\/div><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-k93f\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>The stromal vascular fraction (SVF) obtained from adipose tissue is a biological material with a high content of heterogeneous cell populations such as endothelial cells, preadipocytes, type 2 macrophages, T cells, and pericytes. In particular, SVF contains adipose-derived mesenchymal stem cells (MSCs), which have comparable properties to stem cells from bone marrow.<\/p>\n<p>Mesenchymal stem cells (MSCs) can differentiate into various mesenchymal cell phenotypes. MSCs support cell\u2013cell interactions and play an important role in functional regeneration. MSCs release a wide range of cytokines and growth factors as well as so-called extracellular vesicles (EVs), and thereby essentially exert the following effects:<\/p>\n<ol>\n<li>MSCs modulate inflammatory processes and have anti-inflammatory effects.<\/li>\n<li>MSCs modulate signaling pathways that play a role in the healing process.<\/li>\n<li>MSCs can inhibit osteophyte formation and reduce synovitis.<\/li>\n<li>MSCs have immunomodulatory properties.<\/li>\n<li>MSCs reduce apoptosis.<\/li>\n<\/ol>\n<p>Initial studies show promising results with the use of SVF in alleviating osteoarthritis-related symptoms.<\/p>\n<\/div><\/div><\/div><\/div><\/div><div class=\"w-tabs-section\" id=\"yd1a\"><button class=\"w-tabs-section-header\" aria-controls=\"content-yd1a\" aria-expanded=\"false\"><div class=\"w-tabs-section-title\">Selected literature<\/div><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-yd1a\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>[1] Chiari et al. (2017): Therapeutische Anwendung von Stammzellen in der Orthop\u00e4die. Der Orthop\u00e4de, 12.<br \/>\n[2] Pers et al. (2016): Adipose derived stem cells for regenerative therapy in osteoarticular diseases. Hormone and Molecular Biology and Clinical Investigation, 28(3): 113\u2013120.<br \/>\n[3] Ventura (2022): Lipo-Stem Duo\u2122 Product Characterization. BPB Medica\u2122.<br \/>\n[4] Jimenez-Puerta et al. (2020): Role of Mesenchymal Stromal Cells as Therapeutic Agents: Potential Mechanisms of Action and Implications in Their Clinical Use. Journal of Clinical Medicine, 9, 445.<br \/>\n[5] Mohamed-Ahmed et al. (2018): Adipose-derived and bone marrow mesenchymal stem cells: a donor-matched comparison. Stem Cell Research &amp; Therapy, 9:168.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section>\n","protected":false},"excerpt":{"rendered":"Autologous adipose tissue in osteoarthritis In recent years, many non-surgical options for treating osteoarthritis have become established in Europe. Particularly popular are injections with orthobiologics such as platelet-rich plasma (PRP), hyaluronic acid (HA), and bone marrow aspirate\/concentrate (BMA\/BMAC). In addition, adipose tissue has proven to be a novel and attractive source of stem cells and...","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-4424","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Plasmaconcept - Lipo Stem Duo: Stammzellen aus Fettgewebe<\/title>\n<meta name=\"description\" content=\"Die Stammzelltherapie beschreibt ein Verfahren, bei dem zu n\u00e4chst Stammzellen des Patienten und andere potenziell regenerative Zellen ...\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Plasmaconcept - 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