SYSTEM FOR BONE MARROW ASPIRATION AND CANCELLous BONE HARVESTING
MARROW CELLUTION™ enables optimal cell yield and meets the desire of many users for a single minimal puncture in order to keep patient burden and infection risk as low as possible. It is particularly suitable for the treatment of subchondral pathologies, bone necrosis, and—when combined with Hyalofast®—for the treatment of osteochondral lesions.
Innovation
- Minimizes dilution with peripheral whole blood
- Closed system
- Controlled movement of the cannula within the cavity
Efficiency
- Minimally invasive
- One puncture – multiple aspirations
- Low aspirate volume – high cell yield
- No centrifugation required
Performance
- Higher CFU-f count per ml
- Simultaneous harvesting of autologous bone graft
- Sterile field is not exited
INNOVATIVE SYSTEM FOR BONE MARROW ASPIRATION AND CANCELLous BONE HARVESTING – WITH JUST ONE PUNCTURE
• MARROW CELLUTION™ is an innovative instrument for harvesting bone marrow and cancellous bone
• MARROW CELLUTION™ enables bone marrow aspiration with a high cell concentration
one puncture – multiple aspiration sites within the marrow cavity
• The use of MARROW CELLUTION™ is associated with
significant savings in time and resources
reduced patient trauma
lower morbidity and reduced infection risk
Solutions for every application
To meet the specific needs of users, MARROW CELLUTION™ can be used both for the extraction of concentrated bone marrow aspirate and for the harvesting of autologous cancellous bone.
The functional design of MARROW CELLUTION™ is characterized by two special features that reduce the disadvantages of conventional trocar needles:
- A closed aspiration cannula at the distal end prevents the suction of excess blood from the access channel
- A hand grip with a helical thread allows controlled vertical repositioning of the aspiration point within the marrow cavity
Fig. 1: The distally closed aspiration cannula of MARROW CELLUTION™
The functional design of MARROW CELLUTION™ is characterized by two special features that reduce the disadvantages of conventional trocar needles:
- A closed aspiration cannula at the distal end prevents suction of excess blood from the access channel
- A hand grip with a helical thread enables controlled vertical repositioning of the aspiration point within the marrow cavity
Fig. 2: MARROW CELLUTION™ MC-RAN-8 for percutaneous harvesting of cancellous bone
MAXIMUM CELL YIELD, EASY APPLICATION
Fig. 3: Conventional bone marrow extraction using a trocar
The quality of bone marrow aspirate is measured by the quantity of stem and progenitor cells. Obtaining the highest possible quality aspirate often requires multiple punctures and the collection of small volumes (1–2 ml) from different locations.1–5
If the aspirated volume of 1–2 ml per aspiration site is exceeded, dilution with blood occurs.1–3
Trocar needles with lateral holes aspirate bone marrow primarily through the distal end of the cannula. As a result, the aspirate contains a high proportion of peripheral whole blood. To achieve the desired cell concentration, further processing (e.g., centrifugation) becomes necessary.
Fig. 4: MARROW CELLUTION™
The innovative MARROW CELLUTION™ technology ensures controlled movement of the aspiration cannula within the marrow cavity. This allows aspiration from multiple locations within the marrow space using just a single puncture.
MARROW CELLUTION™ is closed at the distal end and aspirates bone marrow exclusively through holes positioned perpendicular to the insertion channel. This minimizes dilution of the aspirate with peripheral blood. MARROW CELLUTION™ enables optimal cell yield and meets the desire of many users for a single puncture, keeping patient burden and infection risk as low as possible.
Fig. 5: MARROW CELLUTION™ compared with centrifuge systems and conventional trocar needles (comparison of cell yield)
Stem cells – versatile helpers in modern medicine
Stem cells are a heterogeneous group of undifferentiated cells with the ability for long-term self-renewal and plasticity. They can migrate into diseased tissues, produce and secrete bioactive molecules, and can also exert immunosuppressive effects.
According to the German Research Foundation (DFG), stem cells have so far been identified in 20 organs of the human body. They play a key role in embryonic development and regenerative processes. Over the past decades, stem cells have become an important focus of medical research, including in the fields of reconstructive surgery and orthopedics.
The types of stem cells currently in the focus of research are
• embryonic stem cells (ESC)
• induced pluripotent stem cells (iPSC)
• and mesenchymal stem cells (MSC)
MSCs are a group of stem cells that can be obtained from bone marrow.
These so-called BM-MSCs (bone marrow-derived MSCs) have a high regenerative potential and can stimulate healing processes in cartilage and bone.5
