HYALOFAST® is a three-dimensional matrix made of pure hyaluronic acid for the treatment of chondral and osteochondral lesions. HYALOFAST® serves as a scaffold for the settlement of stem cells and cartilage cells and supports them in the regeneration of cartilage tissue.
ONE-STEP CARTILAGE REGENERATION
HYALOFAST® forms a scaffold for mesenchymal stem cells and is used for the treatment of cartilage injuries. These mesenchymal stem cells can be obtained and applied through bone marrow aspirate or concentrate, which is collected during surgery using Marrow Cellution™. They can also migrate into the tissue after bone marrow stimulation or perforation. For the treatment of cartilage defects, bone marrow stimulation—especially nanofracture using NanoFx®—is a common technique to mobilize mesenchymal stem cells from the bone marrow.
Versatile in use
- Indicated for chondral and osteochondral lesions
- Compatible with microfracture and stem cell procedures
Optimal handling
- Easy application via arthroscopy or mini-arthrotomy
- Self-adherent and adaptable
Safe
- Fermentative production
- Based on 20 years of successful application of HYAFF® technology
For the treatment of chondral and osteochondral lesions
HYALOFAST® is a HYAFF®-based three-dimensional matrix made of pure hyaluronic acid for the treatment of chondral and osteochondral lesions of grade III–IV (ICRS classification). The three-dimensional matrix supports stem cells and cartilage cells in their settlement and differentiation. HYALOFAST® thus stimulates natural regeneration and the formation of high-quality, hyaline-like cartilage in a short period of time.
Support for cartilage and bone damage
HYALOFAST® functions as a scaffold for mesenchymal stem cells and takes on a biological role. This core property is successfully used in the treatment of cartilage and bone damage by supporting chondrogenesis.
THE DUAL ROLE OF HYALOFAST®
1. Structure and scaffold for cells
As a three-dimensional tissue, HYALOFAST® promotes the settlement of mesenchymal stem cells while simultaneously contributing to defect filling. HYALOFAST® temporarily replaces the chondral and osteochondral tissue in the lesions until it is resorbed and replaced by new cartilage or bone tissue.
2. Biological support for cartilage regeneration
As a biopolymer made of pure hyaluronic acid, HYALOFAST® enables a controlled release of hyaluronic acid in situ. Mesenchymal stem cells (MSC) are attracted and their differentiation into cartilage or bone tissue is facilitated. Regenerative healing processes are initiated. This biological role makes HYALOFAST® unique worldwide.
Fig. 1: Treatment algorithm according to defect size and ICRS classification
One scaffold – many properties
HYALOFAST® is self-adherent and adaptable to the specific shape of the lesion. There is no need to distinguish between upper and lower sides. Fixation by suturing or gluing is usually not required. In addition, the properties of HYALOFAST® allow for easy arthroscopic implantation. The surgical effort differs little compared to microfracture.
One scaffold – many advantages
HYALOFAST® harnesses the body’s self-healing potential and enables the regeneration of cartilage and bone tissue through a straightforward, minimally invasive surgical procedure. The body’s own cartilage and stem cells independently migrate into the matrix within a short time, multiply, and rebuild the cartilage tissue. The use of HYALOFAST® is therefore extremely patient-friendly and also cost-efficient.
Product: HYAFF®-based three-dimensional matrix
Content: 20 x 20 mm pad made of non-woven fibers
Approval: Medical device with CE marking and MDR approval
Sterilization: Gamma sterilized
Storage: Store dry (< 40° C)
More knowledge, more movement
The evolution of hyaluronic acid
Hyaluronic acid is considered a true all-rounder in medicine: whether as a lubricant and shock absorber in arthritic joints, as a filler for skin wrinkles, or as an artificial tear film in eye drops — hyaluronic acid is used in many ways as a highly viscous and pressure-resistant gel. Through HYAFF® technology (a patented esterification process), hyaluronic acid can be transformed into a biopolymer that modifies its chemical-physical properties while preserving its natural biological advantages.
The esterification process reduces the hydrophilicity of the molecule, making it possible to manufacture medical products that consist of pure hyaluronic acid while taking the form of solid fibers. The HYAFF® technology has been successfully used for 20 years in various medical fields. For the treatment of cartilage damage, HYAFF® technology offers an innovative solution in the form of HYALOFAST®.
